MODELS AND SIMULATIONS
MODELS AND SIMULATIONS
Models and simulations are at the heart of our business.
We develop and adapt all kinds of pharmacoeconomic models:
- decision trees
- Markov and Markov/Monte Carlo models, with probabilistic sensitivity analysis
- fully probabilistic Markov/Monte Carlo models (based on Bayesian statistics)
- DES (Discrete Event Simulation) models
- DICE (Discrete Integrated Competing Events) models
- dynamic transmission models
- hybrid structure models
Development of frequentist (R, STATA) or Bayesian (WinBUGS) statistical models.
MARKET ACCESS
MARKET ACCESS
Dossiers for various decision-making levels
The economic evaluations carried out by our company are fundamental contents of the documentation required to pass the various authorisation stages of your product:
- price and reimbursability request dossier
- reclassification dossier
- PTO dossier – PTOR (Regional Hospital Formulary)
- pre- or post-marketing internal evaluation reports
- marketing and opportunity analysis
HTA reports
Preparation of full or partial HTA reports, depending on customer requirements
Medical Writing
AdRes provides a critical literature review service for technical reports and writing content for submission to scientific journals, conferences and other forms of scientific dissemination.
REAL WORLD EVIDENCE
REAL WORLD EVIDENCE
AdRes organises and coordinates retrospective or prospective observational studies, single or multi-centre, through an all-round management: Planning and design of the study, with drafting of the protocol and the setting up of data collection tools:
- statistical and pharmaco-economic analyses of complete studies and/or preliminary exploratory phases
- engagement and coordination of clinical centres and ethics committees
- organisational and scientific secretariat
AdRes è proprietaria dell’App Easier, sviluppata espressamente per semplificare gli studi di Time&Motion nonchè di diversi Electronic Data Collection Systems, sviluppati per raccolte dati finalizzate a studi prospettici e alla creazione di network specifiche di professionisti.
EVALUATION SCIENTIFIC EVIDENCE
EVALUATION SCIENTIFIC EVIDENCE
Great care and attention are paid to evidence synthesis, which is conducted with different techniques depending on the context, available materials and output required. AdRes has an in-house team specifically dedicated to the activity of identifying, collecting and synthesising scientific evidence:
- review focalizzate, critiche e sistematiche
- metanalisi e network-metanalisi
- trial sequential analysis
- bayesian hierarchical modelling
- valutazione complessiva della qualità delle prove scientifiche, analisi GRADE
MODELS AND SIMULATIONS
Models and simulations are at the heart of our business.
We develop and adapt all kinds of pharmacoeconomic models:
- decision trees
- Modelli di Markov e Markov/Monte Carlo
(microsimulazione a livello paziente) - fully probabilistic Markov/Monte Carlo models (based on Bayesian statistics)
- DES (Discrete Event Simulation) models
- DICE (Discrete Integrated Competing Events) models
- dynamic transmission models
- hybrid structure models
Development of frequentist (R, STATA) or Bayesian (WinBUGS) statistical models.
MARKET ACCESS
Dossiers for various decision-making levels
The economic evaluations carried out by our company are fundamental contents of the documentation required to pass the various authorisation stages of your product:
Preparation of full or partial HTA reports, depending on customer requirements
Medical Writing
AdRes provides a critical literature review service for technical reports and writing content for submission to scientific journals, conferences and other forms of scientific dissemination.
The economic evaluations carried out by our company are fundamental contents of the documentation required to pass the various authorisation stages of your product:
- price and reimbursability request dossier
- reclassification dossier
- PTO dossier – PTOR (Regional Hospital Formulary)
- pre- or post-marketing internal evaluation reports
- marketing and opportunity analysis
Preparation of full or partial HTA reports, depending on customer requirements
Medical Writing
AdRes provides a critical literature review service for technical reports and writing content for submission to scientific journals, conferences and other forms of scientific dissemination.
REAL WORLD EVIDENCE
AdRes organises and coordinates retrospective or prospective observational studies, single or multi-centre, through an all-round management: Planning and design of the study, with drafting of the protocol and the setting up of data collection tools:
- statistical and pharmaco-economic analyses of complete studies and/or preliminary exploratory phases
- engagement and coordination of clinical centres and ethics committees
- organisational and scientific secretariat
EVALUATION SCIENTIFIC EVIDENCE
Great care and attention are paid to evidence synthesis, which is conducted with different techniques depending on the context, available materials and output required. AdRes has an in-house team specifically dedicated to the activity of identifying, collecting and synthesising scientific evidence:
- Focused, critical and systematic reviews
- Metanalysis and network-metanalysis
- Trial sequential analysis
- Bayesian hierarchical modelling
- Overall assessment of the quality of scientific evidence, GRADE analysis
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